preparative reversed-phase hplc system 334 organic pump (Gilson Inc)
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preparative reversed-phase hplc system 334 organic pump
Preparative Reversed Phase Hplc System 334 Organic Pump, supplied by Gilson Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/preparative+reversed-phase+hplc+system+334+organic+pump/preparative+reversed+phase+hplc+system+334+organic+pump/pmc10913065__jo3c02952_si_001-40-8-7
Average 90 stars, based on 1 article reviews
Preparative Reversed Phase Hplc System 334 Organic Pump, supplied by Gilson Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/preparative+reversed-phase+hplc+system+334+organic+pump/preparative+reversed+phase+hplc+system+334+organic+pump/pmc10913065__jo3c02952_si_001-40-8-7
Average 90 stars, based on 1 article reviews
preparative reversed-phase hplc system 334 organic pump - by Bioz Stars,
2026-10
90/100 stars
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Purification:Article Title: Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu 4 ). Article Snippet: This work describes the discovery and characterization of novel 6-((1H-pyrazolo[4,3-b]pyridin3-yl)amino-benzo[d]isothiazolole-3-carboxamides as mGlu4 PAMs.. This scaffold provides improved metabolic clearance and CYP1A2 profiles compared to previously discovered mGlu4 PAMs.. From this work, 27o (VU6001376) was identified as a potent (EC50 = 28 nM, 49% Glu Max) and selective mGlu4 PAM with an excellent rat DMPK profile (in vivo rat CLp = 3.1 mL/min/kg, t1/2 = 445 min, CYP1A2 IC50 > 30 μM). High Performance Liquid Chromatography:Article Title: Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu 4 ). Article Snippet: This work describes the discovery and characterization of novel 6-((1H-pyrazolo[4,3-b]pyridin3-yl)amino-benzo[d]isothiazolole-3-carboxamides as mGlu4 PAMs.. This scaffold provides improved metabolic clearance and CYP1A2 profiles compared to previously discovered mGlu4 PAMs.. From this work, 27o (VU6001376) was identified as a potent (EC50 = 28 nM, 49% Glu Max) and selective mGlu4 PAM with an excellent rat DMPK profile (in vivo rat CLp = 3.1 mL/min/kg, t1/2 = 445 min, CYP1A2 IC50 > 30 μM). Article Title: Rapid sp 3 -Enriched Scaffold Generation via a Selective Aziridine Amide Ring-Opening Reaction Article Snippet: Automated normal phase flash column chromatography was conducted on a Biotage Isolera 1 or a Teledyne ISCO CombiFlash system. .. Reverse Phase HPLC was conducted on a Gilson preparative reversedphase HPLC system comprised of a 333 aqueous pump with solvent-selection valve, Solvent:Article Title: Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu 4 ). Article Snippet: This work describes the discovery and characterization of novel 6-((1H-pyrazolo[4,3-b]pyridin3-yl)amino-benzo[d]isothiazolole-3-carboxamides as mGlu4 PAMs.. This scaffold provides improved metabolic clearance and CYP1A2 profiles compared to previously discovered mGlu4 PAMs.. From this work, 27o (VU6001376) was identified as a potent (EC50 = 28 nM, 49% Glu Max) and selective mGlu4 PAM with an excellent rat DMPK profile (in vivo rat CLp = 3.1 mL/min/kg, t1/2 = 445 min, CYP1A2 IC50 > 30 μM). Article Title: Rapid sp 3 -Enriched Scaffold Generation via a Selective Aziridine Amide Ring-Opening Reaction Article Snippet: Automated normal phase flash column chromatography was conducted on a Biotage Isolera 1 or a Teledyne ISCO CombiFlash system. .. Reverse Phase HPLC was conducted on a Gilson preparative reversedphase HPLC system comprised of a 333 aqueous pump with solvent-selection valve, |